10X

Never mind the museum, I'm waiting for range day!

I'm not going to get too excited about the valve; it opens almost straight down, so a cough or sneeze isn't going to project droplets forward.

It may not have been mentioned in voice or print outside the scientific community. So I'd call the news 'public, for a small group of people, but unknown to most folks'. The press would have had to dig pretty deep to find the references to HC or C as an antiviral--and I don't see them doing that--but within the virology community it was known. The publication in The Virology Journal in 2005 wasn't even the first time the antiviral activity was called out. This publication The Lancet has references citing the antiviral activity going back to at least 1983 Antiviral Activity of Chloroquine Those are some high-profile publications, and I assume they prompted additional work over the years, though like the press, I'm not bothering to dig more deeply. :-) The articles in Virology and elsewhere are why C was one of the first things tested against the new coronavirus. Pharma companies have libraries of millions to tens of millions of compounds stored away. Most didn't do a damned thing useful when they were synthesized as part of some drug discovery effort or other--but they are useful to test when you start the next new drug discovery effort. But where to start? Even the best high-throughput screening program is going to take a lot of time to churn through 10 million compounds. So the process worked pretty much like this, at every pharma company on the planet, starting in March, give or take a few weeks: 1) Test everything we have that has shown activity against any coronavirus (C and HC turned up here) 2) Test everything we have that has shown activity against any virus (Tamiflu, remdesivir, and a few others turned up here) 3) Test everything we have that was made as part of a program to develop antivirals, even if it didn't work against other viruses 4) Test everything else we have in the library; try to figure out some logical order for it, so you test the most promising molecules first 5) Start synthesizing new molecules for testing, incorporating what was learned from steps 1-4 I think every pharma company on the planet completed 1) within a couple of weeks, and I think all were done with 2) and 3) sometime in April. So now everyone is working on 4), which has a low likelihood of success, but you gotta try, and 5), which has the most potential to deliver an effective drug, just not anytime soon.

It wasn’t left out-that early research is why chloroquine/hydroxychloroquine were tested against the new Coronavirus. There was reason to think they might be useful.

Glad to hear it! I've updated my list to show those dies are gone; I know I've got a few new items to add; just need to get downstairs and do an inventory.

For now, restaurant depot is letting the general public in. Not sure how long that will last, probably until the restaurants reopen, but you just walk in, go to customer service, and they hand you a day pass. No need for a membership or tax ID

I made my first visit to Restaurant Depot last week. Wow-quite a place. I'll need to get back when I have more time; it's cool just wandering through the aisles. An hour isn't enough. Among other things, I came back with a whole tenderloin (grilled up a few of those steaks last night) and a whole brisket. That looks like it could take 18 hours or so on the Weber smoker (it's hard to get it up much above 240 F), unless I finish in the oven. I smoked baby back ribs last weekend; three meals worth this past week, and a whole rack frozen for leftovers. I'm smoking chicken leg/thigh quarters today, along with my first attempt at stuffed onions, since I brought home 10 lbs for $4 from Restaurant Depot. The 50 lb bags were $14...

I've been wondering the same. I've read several accounts, none made any mention of the weapon used. Which I found unusual.

You don't need to have a permit to purchase, or an FID card, to go gun shopping and handle the guns. That said, a lot of shops, maybe most, will require that you show an FID before they'll let you touch a gun. If they tell you it's the law, they're lying. If they tell you it's store policy, you're still out of luck, but at least they are being honest about the reason.

I've been happy with topsoil and mulch from Kirk Allen Trucking in Stanhope. Delivery free with 5 yards, as I recall, and you may find a discount coupon online

ANJRPC, tear down this wall!

Yeah. I kinda wish Zeke would go back to talking about his pina colada-flavored meatball recipe. That was slightly less nauseating.

If there is any small good to come from that, it's that some number of Chinese factory workers know that outside of their own Communist government, citizens are allowed to have ammo, and by extension, guns.

My wife got some cell phone footage of a robin that would perch on a patio chair on our deck, then abruptly fly the 12" or so into the glass of one of the living room windows, then bounce back onto the patio chair. It repeated this for EIGHT HOURS today. Good thing it couldn't build up any real momentum.

Hmmm...I could trail the formation in the Skyhawk for a good portion of either route even if I couldn't get a Class B clearance over Philly or the NYC airports during the flyby...shouldn't be lagging more than an hour or two behind the pack the the end of the route. Do you think folks would stay outside the extra time to wave at me? :-)

Once you have the firearm, additional costs you will encounter, in roughly increasing order, are: 1) Firearm accessories 2) Ammo 3) Range Membership 4) More Ammo 5) Your Next Firearm The cycle then repeats, starting with 1).

Been there, still doing that. I've found the easiest approach is to cut the sod over the depression, roll it back to both sides, add topsoil to bring the depression up to the level of the surrounding lawn, then roll the sod back into place, leaving it slightly higher than the surrounding grass, at least for a year or so. Throw a little grass seed into the bare dirt strip where the sod no longer quite touches in the middle. I repeat every few years, but in my experience the depression that forms is a lot smaller than the original stump, so it's not too much of a burden. At least for stumps in the 3' diameter range.

One might think, but you'd still have to move and lose the 5% for the house sale plus closing costs. Oh, plus buy a new house.

They look small enough and with enough room around them that it could be a fun project to fell them yourself, if you know how to do so safely and can get the sequence right to avoid any falling tree getting hung up on a standing tree. But that would leave you with a lot of work to do once the trees are down, and the grinding and grading, would, for most folks, best be left to the professionals. So I understand why moving seems a reasonable alternative! I've got two big, dying ash trees I need to have taken out this year. They're next to the house, so a crane will be required, and the quotes are frighteningly high. Any tree guys here who work in Morris County who want to take a look?

About 2.5 to 3 years for us. As I've said before, on my last day of work I'm taking the loaded moving van to the office, and leaving it parked outside, engine running, pointing west. That's how fast I'm out of here when I retire.

I'm still working more hours than before the madness, but since I can't go anywhere during the downtime, I'm running the smoker every other weekend (baby back ribs are back in the rotation this Sunday) and trying to play more on the lathe. I'm trying to figure out hollowing; I turned a set of shot glasses from some mystery wood, a series of small lidded boxes from dry maple, and just finished a set of three bowls from a freshly-fallen maple tree. Green turning is kinda fun, because the wood cuts so easily and you quickly generate huge piles of long, long shavings. Then the finished bowls warp into cool shapes as they dry, and everyone wonders how you did that... Oh, and I've still got a huge pile of mulch on my driveway. I'm only slowly making progress on getting that spread around.

I'm all for reporting accurately and honestly. I want the data to be as good as possible. I'm not sure I can point to concrete benefits right off the top of my head, and I know there are those who will distort and misuse the data for their own political gain. But I figure it is better that they have to start with good data, rather than use data that is already distorted as their starting point for further distortion!

That is FanfrigginTastic!!!

Pretty cool. I got a kick out of the little dog running for cover at about 2:02, right after the hawk arrives.

I put down a little lime, but mostly tequila.