I know you can buy different slides for different calibers. Are there compatibility concerns or is it all interchangeable?

The mark 1 desert eagle is not interchagable with the others..

 

I have the mark 1 which was 41 mag 44 mag and 357 maximum..

 

The 357 recoil assembly is diffrent than the 41 and 44 mag.

 

xix are the new breed which include 50 cal, those are all interchangable.

What tony said is correct, the Mark I is slightly different than the mark VII and XIX. For the mark XIX, there is a level of parts interchangability that dictates what you would need to buy to do a conversion. The 357 recoil assembly is different (weaker) than the rest so to convert from this caliber up, you would need to swap part of that system out. For the 44, since the 50AE is based on some of the same attributes of the 44rem mag (namely the case head diameter), you can keep the same bolt/breech and simply swap out the barrel and magazine since the bolt works for both. The recoil assembly works for both so that can stay also. this reason alone makes having the 44mag a good choice since its much cheaper to shoot and can be upgraded to 50AE for a minimal cost versus say the 41 corbon or 357.

mark I has no interchangability.

 

mark VII is a bit of a PITA. It really mattered which calibers you were going from/to waht parts you needed to change and if it was possible.

 

Mark XIX was designed to make interchangeability easy. For any given caliber, you need the right bolt, magazine, and barrel. The .357 bolt is different than the bolt shared between the .44 and .50. If you have a .44 or .50, you jsut swap barrels and magazines.

 

Slide is actually shared between all the calibers, as is the frame.

mark I has no interchangability.

 

mark VII is a bit of a PITA. It really mattered which calibers you were going from/to waht parts you needed to change and if it was possible.

 

Mark XIX was designed to make interchangeability easy. For any given caliber, you need the right bolt, magazine, and barrel. The .357 bolt is different than the bolt shared between the .44 and .50. If you have a .44 or .50, you jsut swap barrels and magazines.

 

Slide is actually shared between all the calibers, as is the frame.

 

& expensive