JackDaWack

I'm confused because youre talking about off label prescriptions for non approved FDA drugs... Why don't you just say the drug cant be prescribed, at all, for anything. You've been making claims about off label prescriptions well before Beyer came up..

Imo, Beyer donated all those pill for a reason.. they want what ever government contract is being put together for medical treatment.. if their drug dominates clinical studies.. well that's the name that gets printed on all the literature. If their "novel" form of a generic drug shows promise, the government is more likely to fast track the drugs approval and give them all the money to supply meds.. its get "on label" perscibing authority and the rest is history. Since our government loves to waste money, and loves the pharma industry... my guess is it will work.

If its approved for a condition, it's "on' label.. If it's not listed as an approved FDA treatment, it doesnt matter how similar it is.. it's off label. There is nothing to be confused here, a doctor can write a prescription off label for anything if they feel its medically appropriate. There are drugs out there being used for psychiatric condition's that are not FDA approved for mental health at all, or unrelated mental health disorders. Similarity has nothing to do with this. Doctors read clinical studies all the time to keep up with how a drug can be used to treat a patient, if there is good data on a alread FDA approved drug.. nothing says they cant use it. There is no confusion. The APPROVED drug can be prescribed off label.. if Bayer wants to produce a novel form of the drug to repatent it... that's their business but the government can still solicit any number of pharmaceutical companies to produce the generic APPROVED form. And why wouldnt a company jump on that?

Are you not familiar with off label perscribing?

An Add on charge? Driving Drunk is always illegal... An add on charge is nothing more than something which is normally legal, becomes automatically illegal in the commission of a crime. But thats the point of his example.... If you are stopped for illegal activity, and it leads someone to discover more illegal activity... it does not constitute an add on charge.. I'll give you another example.. you could be driving to the gun range.. which would normally be legal.. lets say the cops stop you and find a dime bag of weed.... the guns are now add on charges to the possession of a CDS N.J.S.A. 2C:39-4.1 makes it a second degree crime to possess a firearm during the course of a CDS crime.

He should at the very least have to explain his rational to their ethics board.

I think its just the way he is trying to describe it. Comparing the effects of say Malaria vs CoVid19. The drug disrupts the ability of cells to digest certain materials, interfering with environmental conditions. In one case you have a direct effect, such as malaria. The drug also accumulates in the protozoa cells themselves, interfering with the pathogen directly. With CoVid 19, it sounds like if im gathering this info correctly the effects are secondary. Cells loose the ability to process the carbohydrate that is attached to cell surface receptors of host target cells. This mean after a few days healthy cells and new cells will loose the tag the virus needs to enter. The drug doesn't disrupt the virus itself, it denies it new host cells to infect.

Sorry with my background that Video was just way to "simple" and made no sense to me.. I look at how the drug actually works: Pharmacodynamics[edit] Antimalarials are lipophilic weak bases and easily pass plasma membranes. The free base form accumulates in lysosomes (acidic cytoplasmic vesicles) and is then protonated,[21] resulting in concentrations within lysosomes up to 1000 times higher than in culture media. This increases the pH of the lysosome from 4 to 6.[22] Alteration in pH causes inhibition of lysosomal acidic proteases causing a diminished proteolysis effect.[23] Higher pH within lysosomes causes decreased intracellular processing, glycosylation and secretion of proteins with many immunologic and nonimmunologic consequences. So it's a localized pH change to cellular lysosomes, which makes MUCH more sense to me now.. This is incredibly promising!!! And THANKS for the info!

from wikipedia "ACE2 is not sensitive to the ACE inhibitor drugs used to treat hypertension"

That's not what the second article you posted said.. " postulated that chloroquine interferes with terminal glycosylation of the angiotensin-converting enzyme 2, the cellular receptor of the SARS-CoV, " What this means is it inhibits the ability of the virus to interact with cell surface receptors to infect new host cells. To me, that description is a direct relation between the drug and a single protein on host cells not being gylcosylated, so its essentially missing its tag the virus attaches to. I doubt pH is the sole reason for this if such a specific response since all proteins are pH senstive.

You need an estate lawyer for all that. Unless you can get the firearms inherited directly to the son, the mom will have to go through all the legal channels or transferring the firearms to him. Wife can verbalize to the lawyer who disposed of the estate and the executor that the father intended for the firearms to go to the son and not her. The lawyer will know how to properly handle this.

He should be fined and suspended from the bench for such a gross disregard of the law.. Everything he said is clearly contradicted by written law.

Not sure what there is to jump on media wise... This is one of those times where the bullshit anti's spread is seen exactly for what it is, when their own sheep are looking to buy guns and cant... pushing the anitgun agenda might just remind them why they are left so helpless and exposed... Better to just keep your mouth shut and not remind your own supporters who made them so vulnerable... when the dust clears and people dont see a need for the guns anymore, they will kick the BS in full gear. Hard to convince someone who wants a gun and cant get one that we need to pass more laws... yey, im sure the many liberals who went to get guns only to be turned away will forget about this all next year..

At best they can "strongly encourage" you to go home...

You could burn all your paperwork today and it wouldn't change a damn thing. You don't have to keep ANY OF IT, including you FPID.. As long as it was legally purchased IN NJ at the point of sale, you are free to transport the guns in NJ as outlined in the law... Handguns to range, smith, home, business. Rifles shotguns and everything else anywhere... The law just says you have to have acquired a FPID to transport long guns.. nothing about whats on it and keeping it with you.

NJ made their FARS system already....

Most my favorite guns I dont use for Home defense... think of it like owning a hammer... does it matter how much you "like" it? Or how well it can do the job? It takes far more training and skill to get the same performance from a lever action over a semiautomatic like ar15. Things to consider are ergonomics, ease of use, rate of failure, minimum level of useful training.. and of course proficiency... If you can shoot one well, quickly and in close quarters then it can work. A short model 1887 is something I will one day have in my "ring of defense", but even then a remington tac13 is probably more reliable

Would you rather have a few magazines pre loaded for home defense? Or try and load a magazine tube during a shoot out? Or even still have to manually load a round after each shot taking you off target. All things that must be taken into consideration when purchasing something for defensive reasons. You definitely want to be comfortable with what you use, if possible I would suggest renting something at a range to try out..

Uhhhh.... Dont like hand guns... ok fine. But why on earth would you limit yourself to these guns for self defense? Which use handgun rounds btw If you want reliable and simple get a pump action shotgun. You want real home defense, ar15 all day.. Contrary to popular belief people buy ar15's because they are just that good for self defense... another than the 22 you listed it has about the same felt recoil as 357 or 45lc You will get many experienced opinions in here, do not discount something because you associate some kind of image with it. 357 is not cheap and neither is 45lc ammo

Careful, credit debt has zero collateral. It will be very interesting to see where that all ends up in 2 months.

I'm struggling with why someone would call 911 if they are sick.. like call the doctor? Go to a hospital?

"when things get bad" sorry that was very subjective.. To me.. I believe it's more about family than personal safety. If cops know their families are safe i would guess a majority would be out there in harms way. I would guess many are scared to bring this illness home with them, too. All responses I can fully understand.. If im at home worrying and protecting mine, i expect no different form someone else. Im not so sure how quickly things can turn for the worst. I have family in cities and they are VERY worried about whats going to happen over the next few days.. My brother wants me to mail him TP, TP!!!! If people dont get what they need in the next few days, things will quickly dissolve. When there is nothing of value to loot from in stores, it will be homes.

Im really curious how many FFL's had to turn away people because they don't have FPID or permits... ya know the oblivious ones...

I think you need to separate a localized short term event from a national emergency where civilization is on the brink of collapsing.. Hurricane Katrina might be a better point of reference here... and they did suspend search and rescues.. and then this: https://www.wave3.com/story/3904630/police-chief-249-new-orleans-officers-left-posts-without-permission-during-katrina/ This is NOT meant to cop bash.. I am not anti-cop... this is just a reality.

Meh, my perspective had always been when things get bad, the cops are gonna worry about themselves first.... it's just now we can see that a bit and it's not even that bad yet.. I dont blame them.. I'm worried for myself and my family and that's just human nature. To me, this is all expected..